Camptothecin ic50
WebAG1024 (IGF-1R抑制剂) 5mg加入1.64ml DMSO,或者每3.05mg加入1ml DMSO,配制成10mM溶液。. SF5409-10mM用DMSO配制。. AG-1024抑制IGF-1R自磷酸化,IC50为7μM,对IR作用效果稍弱,IC50为57μM,且特异性区分InsR和IGF-1R (相比于其他酪氨酸磷酸化抑制剂)。. AG-1024抑制胰岛素类生长因子-1 ... WebDrug: Camptothecin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Camptothecin Drug Target: TOP1 Drug Target …
Camptothecin ic50
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WebJun 15, 2024 · The MCF-7 and MDA-MB-231 human breast cancer cells were treated with the compounds 1 – 7, camptothecin, and etoposide at the 50-µM concentrations for 24 h, and then harvested and washed with cold buffer PBS. Then 5 µL of diluted FLICA reagent and 2 µL of Hoechst 33342 were added to 93 µL of cell suspension and mixed by pipetting. WebAug 15, 2016 · CPT-11 (irinotecan) is a derivative of camptothecin which is a natural product derived from the Chinese tree Camptotheca acuminta and widely used in …
Web9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure. Buy Topoisomerase inhibitor 9-Aminocamptothecin (9-amino-CPT; 9-amino-20(S)-camptothecin) from … WebIn addition, the inhibitory concentration (IC)50 values for cisplatin, docetaxel, camptothecin, and paclitaxel were significantly lower in high-risk patients (Figure 6 (b)-(e)), while there was no ...
WebTo support your products in today’s complex global marketplace, you need an approach that is tailored to your unique product and distribution strategy. WuXi AppTec has supported … WebDrug: Camptothecin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Camptothecin Drug Target: TOP1 Drug Target pathway: DNA replication Dataset GDSC2 Tissue specific analysis Overview IC50 by tissue Volcano Plot Scatter Plot Compare compound IC50 AUC
WebCamptothecin ( CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was …
WebMay 11, 2016 · On the other hand, the same degree of sensitivity from the 2D system did not translate to a 3D culture system, resulting in higher IC50 values than the 2D system. 38 Greatly reduced cell viabilities from DXR treatments were observed from uterus/endometrium cancer (KLE) and colon carcinoma (HCT116), osteogenic sarcoma … aurora heinäpääWebApr 14, 2024 · Paxlovid (ritonavir-boosted nirmatrelvir) is a preferred oral antiviral authorized for the treatment of mild to moderate COVID-19 illness. Patients take a … lauren hutton imdbWebDec 8, 2003 · This enzyme is the sole target of the camptothecin family of anticancer compounds, which acts by stabilizing the covalent protein-DNA complex and enhancing apoptosis through blocking the advancement of replication forks ... Macromolecules Proteins 1 Nucleic Acids / Hybrid 2 Find similar proteins by: (by identity cutoff) 3D Structure aurora health care kaukaunaWebOct 15, 2024 · Then we evaluated the anti-proliferation effect of the two novel derivatives and compared the IC50 with CPT-11. Furthermore, the induction of cell cycle arrest and apoptosis was explored through karyomorphology, flow cytometry (FCM) and Western blot analysis. ... Although the first Camptothecin-like drug, CPT has been discovered for … lauren hutton makeup reviewWebPaclitaxel (taxol) is an anti-mitotic drug that affects microtubule assembly, thereby disrupting microtubule bundle formation (Manfredi et al. 1982 ). Currently, taxol is approved as a first-line chemotherapy drug for breast and ovary cancers. Taxol has different cellular effects depending on its concentration. lauren ilene mirkinWebMar 23, 2015 · Certain benzo[f]indole-4,9-dione derivatives were synthesized and evaluated for their inhibitory effects on superoxide anion generation and neutrophil elastase (NE) release in formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLF)-activated human neutrophils. Results indicated that (Z)-1-benzyl-4-(hydroxyimino)-1H-benzo[f]indol-9(4H)-one (10) … lauren hyslopWebThe present study aims to continue the study of corchorusoside C (1), a cardenolide isolated from Streptocaulon juventas, as a potential anticancer agent. A mechanistic study was … lauren illumination lighting