Dexrazoxane used with doxorubicin
WebHowever, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as …
Dexrazoxane used with doxorubicin
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Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more WebAug 16, 2024 · The suggested dosage ratio of dexrazoxane to doxorubicin is 10 to 1 (e.g., 500 mg/m^2 dexrazoxane to 50 mg/m^2 doxorubicin). It is advisable to give dexrazoxane before doxorubicin. ... The common side effects that culminate from dexrazoxane use include dose-limiting myelotoxicity (neutropenia, leukopenia, granulocytopenia, and …
WebAug 22, 2024 · Administer in a dosage ratio relative to the IV dose of doxorubicin hydrochloride. Adults Prophylaxis of Anthracycline-induced Cardiomyopathy IV. Recommended dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g., 500 mg/m 2 dexrazoxane should be administered with 50 mg/m 2 doxorubicin). Prescribing Limits … WebAug 31, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration. Chemically, dexrazoxane is (S)-4,4'- (1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione. The structural formula is as follows:
WebUse of dexrazoxane as a cardioprotectant in patients receiving doxorubicin or epirubicin chemotherapy for the treatment of cancer. Cancer Prev Control 1999 ;3: 145 - 159 Medline WebNov 5, 2024 · When dexrazoxane injection is used to prevent heart damage caused by doxorubicin, it is given just before each dose of doxorubicin, by intravenous (IV, into a vein) infusion. When used to prevent tissue damage after extravasation, it is given once a day for 3 days, beginning no more than 6 hours after the leakage.
WebJul 15, 2024 · Abstract. Doxorubicin cardiac toxicity is widely misunderstood, largely preventable, and starts with the first dose. This article reviews the history of doxorubicin cardiac toxicity and strategies …
WebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used … how do dog anxiety vests workWebJul 19, 2024 · 1 INDICATIONS AND USAGE. Dexrazoxane for injection is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m 2 and who will continue to receive doxorubicin therapy … how much is gastric sleeve surgery ukWebMar 16, 2024 · In children with cancer, giving dexrazoxane (Zinecard) before each dose of doxorubicin decreases the risk of treatment-related heart problems in adulthood, a new … how much is gatorland for florida residentsWebAnthracyclines such as doxorubicin are widely used chemotherapy drugs in both adults and children for hematologic malignancies, soft-tissue sarcomas, and solid tumors of the breast, lung, stomach, bladder, and ovaries. ... At present, the iron chelator, dexrazoxane, is the only drug approved by the US FDA to counteract anthracycline cardiotoxicity. how much is gatorade paying paige bueckersWebdexrazoxane for cardiomyopathy, reduce the Totect dosage proportionately (maintaining the 10:1 ratio) in patients with hepatic impairment, since a doxorubicin dose reduction is … how much is gasul in the philippinesWebThere is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, and cyclophosphamide (FAC) therapy interferes with the antitumor efficacy of the regimen, and this use is not recommended. ... The recommended dosage ratio of ZINECARD:doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD:50 mg/m2 ... how do dodgem cars workWebDexrazoxane (Cardioxane, Zinecard, a cyclic derivative of edetic acid, is a site-specific cardioprotective agent that effectively protects against anthracycline-induced cardiac … how much is gavi white wine 2021 0751