WebAnastrozole is used to treat breast cancer in women after menopause. Some breast cancers are made to grow faster by a natural hormone called estrogen. Anastrozole decreases the amount of... Web1 feb. 2024 · Anastrozole (Oral Route) Proper Use Drug information provided by: IBM Micromedex Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.
Anastrozole (Oral Route) Description and Brand Names - Mayo …
WebAnastrozole is triazole ring containing non-steroidal aromatase inhibitor. This drug just like another in this category, Letrozole, has the suffix Trozole wh... WebAnastrozole is extensively metabolized in the liver. Metabolism of anastrozole occurs via N-dealkylation, hydroxylation, and glucuronidation. Three metabolites of anastrozole have been identified … inchcape shipping services kenya
Anastrozole metabolic pathways. Anastrozole can be coupled …
The metabolism of anastrozole is by N-dealkylation, hydroxylation, and glucuronidation. [3] Inhibition of aromatase is due to anastrozole itself rather than to metabolites, with the major circulating metabolite being inactive. [6] The elimination half-life of anastrozole is 40 to 50 hours (1.7 to 2.1 days). Meer weergeven Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also … Meer weergeven Breast cancer Anastrozole is used in the treatment and prevention of breast cancer in women. The Arimidex, Tamoxifen, Alone or in Combination … Meer weergeven Common side effects of anastrozole (≥10% incidence) include hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression Meer weergeven Pharmacodynamics Anastrozole works by reversibly binding to the aromatase enzyme, and through competitive inhibition blocks the conversion of Meer weergeven Contraindications of anastrozole include hypersensitivity to anastrozole or any other component of anastrozole formulations, pregnancy, and breastfeeding. Hypersensitivity reactions to anastrozole including anaphylaxis, angioedema, and urticaria have … Meer weergeven Anastrozole is thought to have clinically negligible inhibitory effects on the cytochrome P450 enzymes CYP1A2, CYP2A6 Meer weergeven Anastrozole is a nonsteroidal benzyltriazole. It is also known as α,α,α',α'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile. Anastrozole is structurally related to letrozole, fadrozole, and vorozole, with all being classified as azoles Meer weergeven Web11 mei 2012 · sleep problems. bone pain. headache. swelling. increased cough. shortness of breath. lymphedema (build up of lymph fluid in the tissues of your affected arm) trigger … WebAnastrozole is extensively metabolized in the liver by N-dealkylation, hydroxylation and glucuronidation, therefore, a genetic polymorphism of any enzyme involved in drug detoxification could cause an accumulation of the parental drug or its metabolites, predisposing to liver toxicity [1]. inchcape shipping services klang