Irf transcription factor

Author: rwjj

August undefined, 2024

WebJan 9, 2024 · An expansion in the gene regulatory repertoire controlled by JAK/STAT signaling occurs through the interaction of STATs with IRF transcription factors to form ISGF3, a complex that contains STAT1, STAT2, and IRF9 and regulates expression of IFN-stimulated genes. WebThe interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family.

The IRF Family Transcription Factors in Immunity and Oncogenesis

WebTranscription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. We recently determined that, besides IRF-3 and IRF-7, IRF-5 serves as a direct transducer of virus-mediated signaling. WebHuman immunodeficiency virus type 1 (HIV-1) gene expression is controlled by a complex interplay between viral and host factors. We have previously shown that interferon-regulatory factor 1 (IRF-1) is stimulated early after HIV-1 infection and regulates promoter transcriptional activity even in the absence of the viral transactivator Tat. css background image repeat none

Expression and function of chemokines during viral infections: …

WebInterferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial … WebThe interferon (IFN) regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the IFN-alpha/beta gene promoters, as well as the IFN-stimulated response element (ISRE) of some IFN-stimulated genes. WebHowever, more recent work has indicated that IRF‐3 and IRF‐7 are involved, given the correlation between hantavirus‐induced activation of these two transcription factors and expression of CXCL10 . In the same study, cooperation between IRFs and NF‐κB was again reported, and this cooperation was found to be enhanced in magnitude and ... css background image png

The IRF Family Transcription Factors in Immunity and Oncogenesis

CC chemokine receptor 5 gene promoter activation by the cyclic …

WebIRF8 is a key transcription factor for myeloid cell differentia- tion, and its expression is frequently lost in hematopoietic cells obtained from myeloid leukemia patients. Accumulating evi- dence indicates an antagonizing relationship between IRF8 and myeloid leukemia, in particular chronic myelogenous leukemia (CML). WebThe chemokine receptor CCR5 is implicated in the pathogenesis of various inflammatory diseases, such as multiple sclerosis (MS), atherosclerosis, transplant rejection, and autoimmunity. In previous s earbud with lightning connectorWebInterferon regulatory factor 8 (IRF-8) is a transcription factor that is essential for the normal development of granulocyte/monocyte lineage cells. IRF-8-deficient mice have myeloproliferative disorders and accumulate high levels of MDSCs. css background image pattern

"WebSep 3, 1999 · Interferons are a large family of multifunctional secreted proteins involved in antiviral defense, cell growth regulation and immune activation. Viral infection induces transcription of multiple IFN genes, a response that is in part mediated by the interferon regulatory factors (IRFs). " - Irf transcription factor

Irf transcription factor

WebApr 4, 2024 · The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival. IRF4-Rearranged Large B-Cell Lymphoma on Waldeyer's Ring: A Case Report Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction. WebIRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. Unlike other IRF family members, IRF-4 expression is restricted to lymphoid cells. In B cells, IRF-4 exerts its effects by interacting with PU.1 and binding to ...

Did you know?

WebTranscription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. We recently … WebJul 31, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a …

Web2 days ago · This internalization is crucial for activating IRF-3, which drives IFN-β synthesis, essential for the activation of STAT-1 and consequent synthesis of IRF-1, both crucial transcription factors for the iNOS synthesis and subsequent NO production by LPS-activated macrophages (Fig. 7). Our data contributes to elucidate the role of SRs in the ... WebOct 19, 2005 · Two members of the IFN regulatory factor (IRF) family of transcription factors, IRF-5 and IRF-7, interact with MyD88 and induce proinflammatory cytokines and type I IFNs, respectively. Here, we show that IRF-4 also interacts with MyD88 and acts as a negative regulator of TLR signaling. IRF-4 mRNA is induced by TLR activation, and IRF-4 …

WebMay 31, 2024 · Interferon regulatory factor-5 (IRF5) is a member of the IRF transcription factor family and is important for inducing the innate immune responses mediated by Toll-like receptors (TLRs) that utilize the adaptor protein myeloid differentiation primary response 88 (MyD88) . IRF5 ...

WebApr 17, 2015 · The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation of these two pathways and their interactions during the IIR are only partially known. Results

WebOct 25, 2012 · Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell … earbud with long cordWebSep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs … ear bud wrapWebIRF1 belongs to the Interferon Regulatory Factor family of transcriptional activators and repressors [244], and is responsible for the expression of factors important in innate … ear bud wrapsWebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … earbud with microphone reviewsWebSep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown... css background-image radial-gradientWebOct 6, 2024 · The activation of Nuclear Factor Kappa B (NFκB) and Interferon (IFN) Regulatory Factor (IRF) family transcription factors are of central importance in driving pro-inflammatory and type-I interferon (TI-IFN) gene expression required to effectively restrict spread and trigger adaptive responses leading to clearance. Poxviruses evolve complex ... earbudy llcWebJan 8, 2024 · IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies The induction and action of type I … css background image relative path