Klotho cancer interplay

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August undefined, 2024

WebApr 11, 2024 · Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication. This is the case, for example, with alpelisib, a drug ... WebMay 11, 2024 · Klotho, a type I transmembrane protein, is an important components of FGF receptor complexes. Recent studies have reported the presence of Klotho expression in bone. However, the role of...

What is Klotho? The Klotho Protein - YourDNA

WebJun 17, 2024 · These findings further support the role of Klotho as an anti-tumor gene in human thyroid cancer. Klotho is known as an anti-tumor gene that acts as a circulating hormone to inhibit cancer cell proliferation and migration by modulating tumor-related signal transduction. 9 Our results further reveal that Klotho has an anti-tumor role in RET ... WebAbstract Klotho (KL) gene has been accepted as an "aging suppressor" gene that encodes a single transmembrane protein in human known as Klotho which is commonly expressed … myrtleford mechanics

The interplay of Klotho with signaling pathway and

WebApr 12, 2024 · Transcription factors (e.g., Smad3 and NF-κB) downregulate Klotho and PGC-1α expression, whereas PGC-1α expression is promoted by histone crotonylation. A comprehensive understanding of these mediators might contribute to the establishment of novel therapeutic approaches towards CKD prevention and progression . The mechanism … WebJul 5, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are … myrtleford medical

Klotho Protein for Longevity - Delay Dementia, Kidney Disease

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WebThis review article focuses on the effects of microRNAs on the performance of Klotho and how the interplay between Klotho and certain pathways like insulin-like growth factor, … WebJul 1, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are involved in pancreatic cancer development. We, therefore, undertook to study the expression and activity of klotho in pancreatic cancer. Experimental design: myrtleford newspaperWebFeb 2, 2024 · Background. Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), … the source seattle school district

"WebMar 19, 2013 · Cancer. Cancer Genetics; Gene Regulation & Cell Proliferation; Signal Transduction; Neuroscience. Swartz Foundation; Stanley Institute for Cognitive Genomics; Genomics; ... Computational Cell Biology: The Interplay Between Models and Experimentation , 2013-3-19 - 2013-3-22 File Citation " - Klotho cancer interplay

Klotho cancer interplay

Renal and extrarenal actions of Klotho - PubMed

WebMar 12, 2024 · α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and age-related phenotypes. Pre-clinical evidence suggests that boosting α-Klotho holds therapeutic potential. WebMar 1, 2024 · Methylation-specific PCR was performed to assess DNA methylation of Klotho promoter in the peripheral blood leucocytes (PBLs) from CKD patients and obstructive kidney from UUO mice. CCL5, Klotho, and DNA methyltransferases (DNMTs) were determined by ELISAs, immunofluorescence, or western blotting.

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WebNov 17, 2024 · Klotho Evidence Summary ... cancer. What is it? Klotho (α-Klotho) is located on Chromosome 13, and has been described as an anti-aging gene. It has two major isoforms, a 135 kDa transmembrane protein that serves as an obligatory co-receptor for FGF23, and a 70 kDa secreted form. The transmembrane form is primarily expressed in … WebMay 12, 2024 · Our data indicate that, in accordance with its tumor suppressor activity, klotho differentially interferes with calcium shuttling in cancer cells, but not in normal …

WebMethods: We performed a mass spectrometry (MS) assay to screen candidate proteins complexed with Klotho derived from immunoprecipitation in human non-small cell lung cancer (NSCLC) cells, and ... WebKlotho, a natural human protein has great potential to delay these diseases of aging. Loss of cognition, kidney failure, diabetes, and cancer are all things that are believed to be …

WebOct 1, 2015 · Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both displaying significant homology to members of the β-glycosidase family. Klotho … WebMar 23, 2012 · Quantitative real-time PCR analysis identified frequent elevation of KLB gene expression in HCC tumors relative to matched non-tumor tissue, with a more than two-fold increase correlating with development of multiple tumors in patients. KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling.

WebJun 12, 2024 · The anti-aging factor, klotho has been identified as a tumor suppressor in various human cancers, including lung cancer. In vitro studies provided evidence that …

WebThe potential interplay between tumor cells and sur-rounding senescent stromal cells is largely unexplored. A series of studies have suggested that senescent cells can act as a barrier to cancer development, which has been termed ‘oncogene induced senescence (OIS)’ (Aird and Zhang, 2015). Accumulating evidence has suggested myrtleford neighbourhood centreWebMar 1, 2024 · BackgroundEnhanced inflammation and reduced Klotho are common features in chronic kidney disease (CKD). Inflammation induces DNA hypermethylation. This study assessed the performance of inflammatory marker C-C motif chemokine 5 (CCL5) in epigenetic regulation of Klotho expression.MethodsFifty CKD patients and 25 matched … myrtleford motocross trackWebAcademia.edu is a platform for academics to share research papers. myrtleford neighbourhood houseWebOct 1, 2024 · In various tumor types, Klotho downregulation promotes cell proliferation and reduces cancer cell apoptosis. Soluble Klotho reduces tumor growth in vitro and in vivo in … the source sechelt hoursWebOct 6, 2024 · The potential interplay between tumor cells and surrounding senescent stromal cells is largely unexplored. A series of studies have suggested that senescent … the source sechelt b.cWebApr 11, 2024 · A new study from University of Michigan Rogel Cancer Center researchers surveyed the partners of colorectal cancer patients and found the financial impact of a loved one's diagnosis also impacts ... myrtleford outside school hours careWebOct 1, 2015 · In humans, α-Klotho deficiency or functional variants of α-Klotho are associated with the development of vascular calcification (11, 17), atherosclerosis , diabetes , hypertension , chronic kidney disease , osteoporosis , anemia , and various cancers such as hepatocellular carcinoma , breast cancer , gastric cancer , and renal cell carcinoma . myrtleford mosaic trail