Plants containing thapsigargin
WebThapsigargin, a plant-derived sesquiterpene lactone, has been identified as a non-phorboid tumor promoter whose mode of action appears to result from the emptying of intra- cellular calcium stores (Thastrup, 1990), as a consequence of inhibiting the uptake pathway (Thastrup et al., 1990). WebThapsigargin was originally isolated from the roots of the Mediterranean umbelliferous plant Thapsia garganica in order to characterize the skin irritant principle. Characteristic chemical properties and semi-syntheses are reviewed. The biological activity was related to the subnanomolar affinity for the sarco/endoplasmic reticulum calcium ATPase.
Plants containing thapsigargin
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WebApr 1, 2015 · The sesquiterpene lactone thapsigargin is found in the plant Thapsia garganica L., and is one of the major constituents of the roots and fruits of this Mediterranean species. In 1978, the first... WebJul 2, 2003 · Thapsigargin, purified from the umbelliferous plant Thapsia garganica (12), is a potent (active at nanomolar concentrations) inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump (6,13,14).
WebSep 8, 2024 · Thapsigargin and nortrilobolide are sesquiterpene lactones found in the Mediterranean plant Thapsia garganica L. Thapsigargin is a potent inhibitor of the … Webthe involvement of these cells in the biosynthesis of thapsigargin. This study paves the way for further studies of thapsigargin biosynthesis. Sesquiterpenoids are widely distributed across the plant kingdom and are recogn ized for their pharmaco-logical properties and commercial value (Simonsen et al., 2013).
WebCaspase 12 is a prodeath protease located on the outer surface of the ER membrane and activated by ER stressors such as thapsigargin, tunicamycin, and proinflammatory cytokines in INS-1E cells and human islets [153,154].
Web61 Thapsigargin is found in most parts of the plant T. garganica. Ripe fruits contain the highest 62 amount of thapsigargin with 0.7-1.5% of the dry weight followed by roots (0.2-1.2% d.w.) and 63 leaves (0.1% d.w.) (Smitt et al., 1995). It is well established that many Apiaceae species store
WebNov 19, 2024 · A plant-based antiviral treatment for Covid-19, recently discovered by scientists at the University of Nottingham, has been found to be just as effective at treating all variants of the virus SARS-CoV-2, even the highly infectious Delta variant. ... Thapsigargin is a broad-spectrum inhibitor of major human respiratory viruses: respiratory ... refinish nzWebJul 1, 2024 · Activation of endoplasmic reticulum stress by the natural compound thapsigargin, an emerging new principle to combat coronavirus infections. The endoplasmic reticulum (ER) (see Glossary) is a large, perinuclear organelle that, in a dynamic manner, surveys the folding, assembly, transport, and degradation of membrane and secreted … refinish my patio furnitureWebOct 2, 2015 · Thapsigargin, the first representative of the hexaoxygenated guaianolides, was isolated 40 years ago in order to understand the skin-irritant principles of the resin of the … refinish my hardwood floorsWebThapsigargin is found in most parts of the plant T. garganica. Ripe fruits contain the highest amount of thapsigargin, with 0.7% to 1.5% of the dry weight, followed by roots (0.2%–1.2% of dry weight) and leaves (0.1% of dry weight; Smitt et al., 1995 ). refinish nowWebAug 1, 2002 · A thapsigargin-sensitive Ca 2+ uptake activity was also detected in a cauliflower (Brassica oleracea) Golgi-enriched fraction, suggesting that other plants may also possess thapsigargin-sensitive Golgi Ca 2+ pumps. To our knowledge, this is the first report of a plant Ca 2+ pump activity that shows sensitivity to low concentrations of … refinish my tub souroundWeb14 hours ago · The EPA found samples of “asbestos-containing” debris that was ejected about a mile-and-a-half from the Richmond recycling plant. refinish my tubWebThe guaianolide ring containing sesquiterpene thapsigargin is found in the roots and fruits of Mediterranean plant Thapsia garganica L. It is known for its activity as a potent … refinish non-stick pans