Rbm38 hif1
WebApr 17, 2024 · Increased expression of the HIF1 targets Adm, Vegf, Glut1, Pdk1, and Egl-9 family hypoxia-inducible factor 1 (Egln1) in rod ΔVhl and rod ΔVhl;Hif2a mice verified that HIF1 was transcriptionally ... Webfrom publication: Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, ... (HIF1), a heterodimeric transcription factor, ...
Rbm38 hif1
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WebTogether, our data suggest that RBM38 is a novel translational regulator of HIF1α under a hypoxic condition. Author(s): Cho, Seong-Jun; Teng, I-Fang; Zhang, Min; Yin, Tiffany; Jung, … WebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl …
WebFeb 15, 2024 · The p63 transcription factor, a p53 family protein, regulates genes involved in various cellular processes, including cell growth and differentiation. We previously showed that RNA-binding motif protein (Rbm38) is a p63 target and, in turn, regulates p63α mRNA stability by binding to the AU/U-rich e … WebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to …
WebApr 1, 2024 · Interestingly, RBM38 is unique in that it can either suppress or enhance p53 mRNA translation via altered interaction with eIF4E potentially mediated by serine-195 (S195) in RBM38. Thus, multiple RBM38/eIF4E knock-in (KI) cell lines were generated to investigate the significance of eIF4E-RBM38 interaction in controlling p53 activity. WebMar 9, 2024 · RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway. [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability]. RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR …
WebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl hydroxylase and rapidly degraded through the VHL-mediated proteasomal pathway . Once ... RBM38 prevents eIF4E from binding HIF1α transcript (A) ...
WebThe RNA-binding protein Rbm38, also called RNPC1, is a 7, 8). Rbm38 is found to regulate expression of genes necessary for several cellular processes, including cell growth and differenti-ation. For example, Rbm38 is found to regulate Mdm2, p21, p73, and Pten mRNA stability through binding to the AU/U-rich elements in their 3UTRs ( 8–11). solvent cartridges tech supportWebfrom publication: Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, ... (HIF1), a heterodimeric transcription factor, ... solvent cabinet laboratoryWebfactor family are targeted by Rbm38, either through RNA stability or RNA translation. Among these family members, Rbm38 stabilizes mRNAs of p21 and p73, while it destabilizes p63 mRNA [9, 11, 22]. Interestingly, phosphorylation of Rbm38 by glycogen synthase kinase 3 (GSK3) converts Rbm38 from a translational repressor to an activator [24 ... solvent cabinet heaterWebMar 21, 2024 · Background: Current studies have revealed that RNA-binding protein RBM38 is closely related to tumor development, while its role in malignant melanoma remains unclear. Therefore, this research aimed to investigate the function of RBM38 in melanoma and the prognosis of the disease. Methods: Functional experiments (CCK-8 assay, cell … solvent casting and particulate leachingWebFrom the oncology field is known that Rbm38 has a role in the stabilization of the cell cycle inhibitor p21. 8, 25 Indeed we found silencing of Rbm38 to significantly inhibit p21 levels which was ... solvent brush with hoseWebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA. In this study, we show that synthetic peptides corresponding to the binding interface between Rbm38 and eIF4E, including an 8 amino acid peptide (Pep8) derived … small brokerage accountWebHere, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies in mice deficient … small broken heart tattoo